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KMID : 0367419740150060086
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Journal of Korean Pediatric Society
1974 Volume.15 No. 6 p.86 ~ p.94
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Lactic Dehydrogenase Activity in the Serum of Brain Damaged Rabbits
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金相協/Kim, Sang Hyeup
李國柱/申星雨/Rie, Kook Choo/Shin, Sung Woo
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Abstract
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Estimation of the levels of tissue enzymes in the circulating blood has become a useful aid to diagnosis of cell damage in many organs, but enzymes changes in the blood following brain damage have been found to be inconstant.
In order to clarify it, authors carried out investigation of changes of serum lactic dehydrogenase in experimentally induced rabbit brain injury.
Following injection of 0.05 ml of 0.1% AgNO(_3) solution into the rabbit brain by stereotaxic apparatus, we examined serum lactic dehydrogenase activity by spectrophotometer.
the following results were obtained.
1. Marked elevation of LDH, above 1000 u/ml of mean value, were observed in caudate nucleus, globus pallidus and midbrain.
2. Moderate elevation of LDH, between 500 u/ml and 1,000 u/ml were observed in mammillary body, hippocampus, putamen and amygdala.
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